JCI insight · 2017
A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Judge Luke M, Perez-Bermejo Juan A, Truong Annie, Ribeiro Alexandre Js, Yoo Jennie C, Jensen Christina L, Mandegar Mohammad A, Huebsch Nathaniel, Kaake Robyn M, So Po-Lin, Srivastava Deepak, Pruitt Beth L, Krogan Nevan J, Conklin Bruce R
Аннотация
PURPOSE: The aim of the current study is to investigate the efficacy of lidocaine 2% gel for the control of pain experienced after pterygium surgery.
METHODS: We conducted a prospective, randomized clinical trial on 45 eyes of 45 patients who underwent pterygium surgery. The patients were randomized into 2 groups. Group 1 was provided with topical 2% lidocaine gel and group 2 with artificial tear gel. The primary outcome of interest was the pain experienced at the 4th, 7th and 10th postoperative hours. Corneal reepithelization was evaluated by slitlamp biomicroscopy. Pain was determined using a 10-point linear visual analogue scale. No systemic analgesic or topical nonsteroidal anti-inflammatory drop was administered.
RESULTS: The groups had similar demographic data. The mean pain scores of the study and the control groups according to the visual analogue scale were: 4.13 +/- 1.86 and 6.50 +/- 1.47 (p = 0.001) at the 4th postoperative hour, 4.00 +/- 1.16 and 4.00 +/- 1.16 (p = 0.001) at the 7th , and 2.39 +/- 0.89 and 3.63 +/- 1.00 (p = 0.001) at the 10th postoperative hour, respectively. The mean area of the corneal epithelial defect in the lidocaine gel group was 4.78 +/- 1.04 mm2 and 4.68 +/- 0.89 in the artificial tear gel group (p = 0.42). The mean corneal reepithelization time was 37.56 +/- 10.42 h in the lidocaine gel group and 34.36 +/- 10.00 h in the artificial tear gel group (p = 0.26). There were no side effects related to the drugs observed in either of the 2 treatment groups.
CONCLUSION: We conclude that topical lidocaine gel is an effective and safe anesthetic agent for the control of pain experienced shortly after pterygium surgery.
METHODS: We conducted a prospective, randomized clinical trial on 45 eyes of 45 patients who underwent pterygium surgery. The patients were randomized into 2 groups. Group 1 was provided with topical 2% lidocaine gel and group 2 with artificial tear gel. The primary outcome of interest was the pain experienced at the 4th, 7th and 10th postoperative hours. Corneal reepithelization was evaluated by slitlamp biomicroscopy. Pain was determined using a 10-point linear visual analogue scale. No systemic analgesic or topical nonsteroidal anti-inflammatory drop was administered.
RESULTS: The groups had similar demographic data. The mean pain scores of the study and the control groups according to the visual analogue scale were: 4.13 +/- 1.86 and 6.50 +/- 1.47 (p = 0.001) at the 4th postoperative hour, 4.00 +/- 1.16 and 4.00 +/- 1.16 (p = 0.001) at the 7th , and 2.39 +/- 0.89 and 3.63 +/- 1.00 (p = 0.001) at the 10th postoperative hour, respectively. The mean area of the corneal epithelial defect in the lidocaine gel group was 4.78 +/- 1.04 mm2 and 4.68 +/- 0.89 in the artificial tear gel group (p = 0.42). The mean corneal reepithelization time was 37.56 +/- 10.42 h in the lidocaine gel group and 34.36 +/- 10.00 h in the artificial tear gel group (p = 0.26). There were no side effects related to the drugs observed in either of the 2 treatment groups.
CONCLUSION: We conclude that topical lidocaine gel is an effective and safe anesthetic agent for the control of pain experienced shortly after pterygium surgery.