PLoS neglected tropical diseases · 2025
Cognitive impairment in Chagas disease patients in Brazil, 2007-2021: A cross-sectional study.
СтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Serrano Carla J, Lisbôa-Marques Maria E, Cerqueira-Silva Thiago, B Santos Leila S, Oliveira Murilo A, Ferreira Felix Iuri, de Sousa Paulo R S P, Cardoso Leonardo G M, Muiños Pedro J R, Maia Renata M, Catto Marília B, Wittlich Eric Aguiar, Rodrigues-Ribeiro Lucy, Botelho Victor L P P, Nunes Maria Carmo P, Ribeiro Antonio Luiz P, Barbosa E Silva Lucas C, Aras Roque, Furie Karen L, Oliveira Filho Jamary
Аннотация
INTRODUCTION: Chagas Disease (CD) is frequently associated with heart failure (HF). Cognitive impairment is reported, but whether it results from CD or is a nonspecific symptom of HF is unknown. We aimed to compare cognitive function of HF patients with or without CD.
METHODS: Multicenter cross-sectional study of HF patients. Investigators blinded to the etiology of HF evaluated global cognition and domains of memory, executive and visuospatial function. Logistic regression tested the association between CD and cognitive impairment (Z-score < -1.5) in each domain adjusted for age, sex, educational level and left ventricular ejection fraction.
RESULTS: We recruited 518 patients, 250 (48.3%) with CD. Cognitive impairment was more common in CD vs. non-CD patients (27.1% vs 13.1%, p < 0.001), mostly in memory (10.4% vs 5.0%, p = 0.022) and visuospatial function (45.2% vs 29.6%, p < 0.001). In the multivariable analysis, CD remained associated with global cognitive impairment (odds ratio 1.90; 95% CI 1.13-3.21, p = 0.016) and visuospatial function impairment (OR 1.56; 95% CI 1.02-2.39, p = 0.039).
DISCUSSION: Chagas disease is associated with cognitive impairment independently of heart failure severity, suggesting other competing mechanisms.
METHODS: Multicenter cross-sectional study of HF patients. Investigators blinded to the etiology of HF evaluated global cognition and domains of memory, executive and visuospatial function. Logistic regression tested the association between CD and cognitive impairment (Z-score < -1.5) in each domain adjusted for age, sex, educational level and left ventricular ejection fraction.
RESULTS: We recruited 518 patients, 250 (48.3%) with CD. Cognitive impairment was more common in CD vs. non-CD patients (27.1% vs 13.1%, p < 0.001), mostly in memory (10.4% vs 5.0%, p = 0.022) and visuospatial function (45.2% vs 29.6%, p < 0.001). In the multivariable analysis, CD remained associated with global cognitive impairment (odds ratio 1.90; 95% CI 1.13-3.21, p = 0.016) and visuospatial function impairment (OR 1.56; 95% CI 1.02-2.39, p = 0.039).
DISCUSSION: Chagas disease is associated with cognitive impairment independently of heart failure severity, suggesting other competing mechanisms.