Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology · 2015
Carotid aneurism with acute dissection: an unusual case of IgG4-related diseases.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Barp Andrea, Fedrigo Marny, Farina Filippo Maria, Lepidi Sandro, Causin Francesco, Castellani Chiara, Cester Giacomo, Thiene Gaetano, Valente Marialuisa, Baracchini Claudio, Angelini Annalisa
Аннотация
AIM: IgG4-related disease is a systemic disease that involves organs and vascular structures, in particular, the aorta. This is the first case that showed the carotid artery involvement with dissection evolution.
METHODS AND RESULTS: In a 67-year-old man with speech impairment and right-hand clumsiness, a brain computed tomography revealed signs of acute ischemia in the left frontal lobe while an echo-color Doppler sonography of the cervical vessels showed a tight stenosis of left internal carotid artery with a large pseudoaneurysm. Histological findings performed on the surgical specimen disclosed IgG4-related disease.
CONCLUSIONS: To the best of our knowledge, this is the first manifestation of IgG4-related disease with carotid artery dissection complicated by pseudoaneurysm. Even though unsuccessful since the patients died within 48 h, this case highlights the diverse facets of the IgG4-related disease representing a new complication with important clinical implications of such a diagnosis targeting immunosuppressive therapy particularly B-cell depletion.
METHODS AND RESULTS: In a 67-year-old man with speech impairment and right-hand clumsiness, a brain computed tomography revealed signs of acute ischemia in the left frontal lobe while an echo-color Doppler sonography of the cervical vessels showed a tight stenosis of left internal carotid artery with a large pseudoaneurysm. Histological findings performed on the surgical specimen disclosed IgG4-related disease.
CONCLUSIONS: To the best of our knowledge, this is the first manifestation of IgG4-related disease with carotid artery dissection complicated by pseudoaneurysm. Even though unsuccessful since the patients died within 48 h, this case highlights the diverse facets of the IgG4-related disease representing a new complication with important clinical implications of such a diagnosis targeting immunosuppressive therapy particularly B-cell depletion.