Journal of veterinary science · 2026
Unilateral congenital testicular seminoma in a neonatal Holstein calf: gross, histopathological, and immunohistochemical characterization.
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Yang Seongmo, Kim Sanggu, Park Moochang, Kim Soochong
Аннотация
IMPORTANCE: This case report presents a rare case of unilateral congenital testicular seminoma in a neonatal Holstein calf.
CASE PRESENTATION: A neonatal male Holstein calf was presented with a unilaterally enlarged inguinal mass, which was identified immediately after birth. The calf was euthanized at the farmer's request, and both testes were collected for pathological examination. Gross examination of the excised testes revealed a right-sided unilateral testicular neoplasm with a normal contralateral testis. The cut surface was gray to pink with multifocal hemorrhage, congestion, and cystic degeneration. Histologically, the mass was lobulated by fibrous trabeculae, and neoplastic cells were round to oval with scant clear cytoplasm. Notable features included prominent nucleoli, clumped chromatin, severe anisocytosis and anisokaryosis, and a total of 18 mitotic figures counted across 10 high-power fields (HPFs) (18 mitoses/10HPFs; mean, 1.8 mitoses/HPF). Histological findings suggested seminoma as an initial diagnosis. However, the tumor also showed distinct microcystic patterns, which prompted the consideration of yolk sac tumor as a differential diagnosis. Immunohistochemically, the neoplastic cells showed cytoplasmic positivity for CD117, whereas pancytokeratin was negative, confirming the diagnosis of seminoma.
CONCLUSIONS AND RELEVANCE: To the best of our knowledge, this is the first case of unilateral congenital seminoma in a neonatal Holstein calf.
CASE PRESENTATION: A neonatal male Holstein calf was presented with a unilaterally enlarged inguinal mass, which was identified immediately after birth. The calf was euthanized at the farmer's request, and both testes were collected for pathological examination. Gross examination of the excised testes revealed a right-sided unilateral testicular neoplasm with a normal contralateral testis. The cut surface was gray to pink with multifocal hemorrhage, congestion, and cystic degeneration. Histologically, the mass was lobulated by fibrous trabeculae, and neoplastic cells were round to oval with scant clear cytoplasm. Notable features included prominent nucleoli, clumped chromatin, severe anisocytosis and anisokaryosis, and a total of 18 mitotic figures counted across 10 high-power fields (HPFs) (18 mitoses/10HPFs; mean, 1.8 mitoses/HPF). Histological findings suggested seminoma as an initial diagnosis. However, the tumor also showed distinct microcystic patterns, which prompted the consideration of yolk sac tumor as a differential diagnosis. Immunohistochemically, the neoplastic cells showed cytoplasmic positivity for CD117, whereas pancytokeratin was negative, confirming the diagnosis of seminoma.
CONCLUSIONS AND RELEVANCE: To the best of our knowledge, this is the first case of unilateral congenital seminoma in a neonatal Holstein calf.