The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2004
Analysis of survivors more than 10 years after heart transplantation in the cyclosporine era: Stanford experience.
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Shiba Nobuyuki, Chan Michael C Y, Kwok Bernard W K, Valantine Hannah A, Robbins Robert C, Hunt Sharon A
Аннотация
BACKGROUND: Truly long term survival post heart transplantation has become increasingly frequent over the past two decades.
METHODS: We analyzed multiple clinical outcomes in the cohort of 140 patients in the Stanford database who underwent heart transplantation after the introduction of cyclosporine-based immunosuppression in 1980 and survived >10 years after transplantation.
RESULTS: We found generally excellent functional status in these patients, but a high incidence of hypertension, renal dysfunction, and graft CAD as well as malignancy.
CONCLUSION: With continued improvement in post-transplant survival rates, providing complex care for such long-term recipients as these will assume increasing clinical importance in the everyday practice of transplant medicine and these data highlight the problems to be anticipated.
METHODS: We analyzed multiple clinical outcomes in the cohort of 140 patients in the Stanford database who underwent heart transplantation after the introduction of cyclosporine-based immunosuppression in 1980 and survived >10 years after transplantation.
RESULTS: We found generally excellent functional status in these patients, but a high incidence of hypertension, renal dysfunction, and graft CAD as well as malignancy.
CONCLUSION: With continued improvement in post-transplant survival rates, providing complex care for such long-term recipients as these will assume increasing clinical importance in the everyday practice of transplant medicine and these data highlight the problems to be anticipated.