Nature genetics · 2012
Whole-genome sequence of Schistosoma haematobium.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Young Neil D, Jex Aaron R, Li Bo, Liu Shiping, Yang Linfeng, Xiong Zijun, Li Yingrui, Cantacessi Cinzia, Hall Ross S, Xu Xun, Chen Fangyuan, Wu Xuan, Zerlotini Adhemar, Oliveira Guilherme, Hofmann Andreas, Zhang Guojie, Fang Xiaodong, Kang Yi, Campbell Bronwyn E, Loukas Alex, Ranganathan Shoba, Rollinson David, Rinaldi Gabriel, Brindley Paul J, Yang Huanming, Wang Jun, Wang Jian, Gasser Robin B
Аннотация
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.