Journal of affective disorders · 1999
Early- versus late-onset dythymic disorder: comparison in out-patients with superimposed major depressive episodes.
Клиническое исследованиеСравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Klein D N, Schatzberg A F, McCullough J P, Keller M B, Dowling F, Goodman D, Howland R H, Markowitz J C, Smith C, Miceli R, Harrison W M
Аннотация
BACKGROUND: This study examined the validity of the early-late onset subtyping distinction in dysthymic disorder.
METHODS: Participants were 340 out-patients meeting DSM-III-R criteria for dysthymia and a concurrent major depressive episode (MDE). The sample was drawn from a 12-site double-blind randomized parallel group trial comparing the efficacy of sertraline and imipramine in the treatment of chronic depression. All patients received comprehensive evaluations using semi-structured interviews and rating scales.
RESULTS: 73% of the sample met criteria for the early-onset, and 27% for the late-onset, subtype. The early-onset patients had a significantly longer index MDE, significantly higher rates of personality disorders and lifetime substance use disorders, and a significantly greater proportion had a family history of mood disorder. The subgroups did not differ in symptom severity or functional impairment at baseline, nor in response to a 12-week trial of antidepressants.
LIMITATIONS: Further work is needed to extend these findings to dysthymic disorder without superimposed MDEs.
CONCLUSIONS: These results support the distinction between early-onset and late-onset dysthymic disorder.
METHODS: Participants were 340 out-patients meeting DSM-III-R criteria for dysthymia and a concurrent major depressive episode (MDE). The sample was drawn from a 12-site double-blind randomized parallel group trial comparing the efficacy of sertraline and imipramine in the treatment of chronic depression. All patients received comprehensive evaluations using semi-structured interviews and rating scales.
RESULTS: 73% of the sample met criteria for the early-onset, and 27% for the late-onset, subtype. The early-onset patients had a significantly longer index MDE, significantly higher rates of personality disorders and lifetime substance use disorders, and a significantly greater proportion had a family history of mood disorder. The subgroups did not differ in symptom severity or functional impairment at baseline, nor in response to a 12-week trial of antidepressants.
LIMITATIONS: Further work is needed to extend these findings to dysthymic disorder without superimposed MDEs.
CONCLUSIONS: These results support the distinction between early-onset and late-onset dysthymic disorder.