Characteristics and Survival Results of Peritoneal Dialysis Patients Suffering from COVID-19 in Turkey: A Multicenter National Study.
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Gursu Meltem, Ozturk Savas, Arici Mustafa, Sahin Idris, Gokcay Bek Sibel, Yilmaz Murvet, Koyuncu Sumeyra, Karahisar Sirali Semahat, Ural Zeynep, Dursun Belda, Yuksel Enver, Uzun Sami, Sipahi Savaş, Ahbap Elbis, Artan Ayse Serra, Altunoren Orcun, Tunca Onur, Ayar Yavuz, Gok Oguz Ebru, Yilmaz Zulfukar, Kahvecioglu Serdar, Asicioglu Ebru, Oruc Aysegul, Altiparmak Mehmet Riza, Aydin Zeki, Huddam Bulent, Dolarslan Murside Esra, Azak Alper, Bakırdogen Serkan, Yalcin Ahmet Ugur, Karadag Serhat, Ulu Memnune Sena, Gungor Ozkan, Ari Bakir Elif, Odabas Ali Rıza, Seyahi Nurhan, Yildiz Alaattin, Ates Kenan
Аннотация
METHODS: In this multicenter national study, we included PD patients with confirmed COVID-19 from 27 centers. The baseline demographic, clinical, laboratory, and radiological data and outcomes at the end of the first month were recorded.
RESULTS: We enrolled 142 COVID-19 patients (median age: 52 years). 58.2% of patients had mild disease at diagnosis. Lung involvement was detected in 60.8% of patients. Eighty-three (58.4%) patients were hospitalized, 31 (21.8%) patients were admitted to intensive care unit and 24 needed mechanical ventilation. Fifteen (10.5%) patients were switched to hemodialysis and hemodiafiltration was performed for four (2.8%) patients. Persisting pulmonary symptoms (n = 27), lower respiratory system infection (n = 12), rehospitalization for any reason (n = 24), malnutrition (n = 6), hypervolemia (n = 13), peritonitis (n = 7), ultrafiltration failure (n = 7), and in PD modality change (n = 8) were reported in survivors. Twenty-six patients (18.31%) died in the first month of diagnosis. The non-survivor group was older, comorbidities were more prevalent. Fever, dyspnea, cough, serious-vital disease at presentation, bilateral pulmonary involvement, and pleural effusion were more frequent among non-survivors. Age (OR: 1.102; 95% CI: 1.032-1.117; p: 0.004), moderate-severe clinical disease at presentation (OR: 26.825; 95% CI: 4.578-157.172; p < 0.001), and baseline CRP (OR: 1.008; 95% CI; 1,000-1.016; p: 0.040) were associated with first-month mortality in multivariate analysis.
DISCUSSION/CONCLUSIONS: Early mortality rate and medical complications are quite high in PD patients with COVID-19. Age, clinical severity of COVID-19, and baseline CRP level are the independent parameters associated with mortality.