Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2020
Clinical characteristics of familial schizophrenia.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Liu Na, Zhou Hui, Xiong Xiangyu, Li Qingwei, Jiang Xuefeng, Zhao Jingping, Yang Xiaoxin, Zhang Mingyuan, Wang Xiangqun, Wang Gang, Yang Fude, Hu Jian, Zhang Xinjun, Du Lingyang, Li Huichun, Feng Bing, Hu Zhenyu, Chen Zuoming, Wang Chunxia, Wang Xilin, Zhang Jinbei, Liu Tiebang, Jia Fujun, Sun Xueli, Xu Xiufeng, Meng Huaqing, Wang Gaohua, Zhang Ning, Mei Qiyi, Tan Qingrong, Peng Chunqing, Li Jing, Lu Zheng
Аннотация
INTRODUCTION: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated.
METHODS: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia.
RESULTS: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease.
CONCLUSION: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.
METHODS: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia.
RESULTS: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease.
CONCLUSION: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.