Revue des maladies respiratoires · 2003
[Cutaneous adverse drug reaction with pulmonary involvement].
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Wolkenstein P, Chosidow O
Аннотация
INTRODUCTION: Cutaneous adverse drug reactions can be life-threatening: toxic necrolis and hypersensitivity syndrome or DRESS ("Drug Rash with Eosinophilia and Systemic Symptoms").
STATE OF THE ART: Pulmonary involvement is considered as a severity factor. During toxic epidermal necrolysis, pulmonary involvement is present in about 25% of cases; it corresponds to the detachment and the necrosis of bronchial epithelium. Specific bronchial involvement is of poor prognosis. During DRESS, pulmonary involvement is rare corresponding to an interstitial pneumonia with eosinophils.
PERSPECTIVES: Progress in the knowledge of pathophysiology will help to target therapeutics.
CONCLUSIONS: Early recognition of pulmonary complications must lead to adapt treatment and to improve prognosis.
STATE OF THE ART: Pulmonary involvement is considered as a severity factor. During toxic epidermal necrolysis, pulmonary involvement is present in about 25% of cases; it corresponds to the detachment and the necrosis of bronchial epithelium. Specific bronchial involvement is of poor prognosis. During DRESS, pulmonary involvement is rare corresponding to an interstitial pneumonia with eosinophils.
PERSPECTIVES: Progress in the knowledge of pathophysiology will help to target therapeutics.
CONCLUSIONS: Early recognition of pulmonary complications must lead to adapt treatment and to improve prognosis.