European journal of case reports in internal medicine · 2026
Coexisting Waldenström Macroglobulinaemia and Alveolar Echinococcosis Presenting with Chylothorax that Resolved on Treatment: A Diagnostic and Therapeutic Challenge.
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Perramond François, Bugnon Serge, Voegeli Jérôme, Berzigotti Annalisa
Аннотация
INTRODUCTION: Waldenström macroglobulinaemia is a lymphoplasmacytic lymphoma producing monoclonal immunoglobulin M (IgM), and both the disease and its treatment can cause immunosuppression. Alveolar echinococcosis is a parasitic infection that primarily involves the liver but may present with extrahepatic manifestations.
CASE DESCRIPTION: We report the case of a patient who presented with chylothorax and non-specific hepatic lesions and was then diagnosed with Waldenström macroglobulinaemia. In addition to this diagnosis, alveolar echinococcosis was subsequently confirmed by liver biopsy and serology.
DISCUSSION: Diagnostic interpretation was challenging, as these features may occur in both conditions. A multidisciplinary approach was needed to establish the treatment plan due to overlapping symptomatology and the risk of treatment-related immunosuppression.
CONCLUSION: This case highlights the importance of considering a broad differential diagnosis for a chylothorax and hepatic lesions in an oncological context and illustrates the therapeutic challenges of managing an indolent haematologic malignancy in the context of a chronic parasitic infection.
LEARNING POINTS: Chylothorax has a large differential diagnosis and is often difficult to treat.Echinococcosis can clinically and radiologically mimic malignancy.The investigation and management of a patient with both conditions are challenging.
CASE DESCRIPTION: We report the case of a patient who presented with chylothorax and non-specific hepatic lesions and was then diagnosed with Waldenström macroglobulinaemia. In addition to this diagnosis, alveolar echinococcosis was subsequently confirmed by liver biopsy and serology.
DISCUSSION: Diagnostic interpretation was challenging, as these features may occur in both conditions. A multidisciplinary approach was needed to establish the treatment plan due to overlapping symptomatology and the risk of treatment-related immunosuppression.
CONCLUSION: This case highlights the importance of considering a broad differential diagnosis for a chylothorax and hepatic lesions in an oncological context and illustrates the therapeutic challenges of managing an indolent haematologic malignancy in the context of a chronic parasitic infection.
LEARNING POINTS: Chylothorax has a large differential diagnosis and is often difficult to treat.Echinococcosis can clinically and radiologically mimic malignancy.The investigation and management of a patient with both conditions are challenging.