Prevalence of hyperlipoproteinemia in men with gallstone disease.

Lipoprotein disorders are associated with changes in the bile lipid composition, and gallstone disease has been reported to be common in hyperlipoproteinemic patients. To find out whether there is a significant correlation between hyperlipoproteinemia and gallstone disease, we compared the prealence of hyperlipoproteinemia in a consecutive series of male gallstone patients with that in an age-matched consecutive series of gallstone-free patients. The gallstone patients were hyperlipoproteinemic in 43.5% as compared with 22.5% in the control patients. This difference was statistically significant. Prebetahyperlipoproteinemia (type IV) was the most common lipoprotein disorder in gallstone patients as well as in control patients.