Recurrent oral erythema multiforme: a case series report and review of the literature.

Recurrent oral erythema multiforme (ROEM) is now accepted as a less-recognized subtype of erythema multiforme (EM). The diagnosis is based on the exclusion of other similar diseases; typical clinical features, such as mutiple recurrent irregular painful erosions of oral mucosa without skin lesions, and, frequently, evidence of past herpes simplex virus infection. Here, we report 3 cases diagnosed as ROEM according to the 3 characteristics mentioned before. In addition, the article reviews the epidemiology, etiology, clinical manifestations, basis for diagnosis, and treatment of ROEM and highlights the need for prophylaxis.