Investigating the properties of electrospun nanofibers made of hybride polymer containing anticoagulant drugs.

The aim of this study is to provide a scaffold made of chitosan/polyvinylalcohol/ Polyurethane /polyaniline/Zingiber officinal (CS//PVA/PU/PANI/Zin) and heparin (CS//PVA/PU/PANI/HEP) with double-needle electrospinning that contains anticoagulant drugs. The medicine that was loaded on the nanofibers was measured with FT-IR, SEM, XRD, ZPS, and RSM, TST and AFM. In vitro release of loading drugs was measured at room temperature and at pH = 5.3 and pH = 7.4. The kinetic release of the drugs was studied and their cytotoxicity was assessed with MTT assay, HT, coagulation[(PT), PTT, and INR test], and TST. Based on the in vitro release studies, about 73.62% and 73.40%, respectively, of Zin and heparin were put in a medium with pH = 7.4. The results indicated that a heart valve with high tensile strength and anticoagulant properties had been developed. Clinically, due to the structural similarity of the polyurethane, biocompatibility and blood compatibility were improved in the presence of Zin extract.