Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Harboe Zitta Barrella, Hamm Sebastian Rask, Pérez-Alós Laura, Sivapalan Pradeesh, Priemé Helene, Wilcke Torgny, Kjeldgaard Peter, Shaker Saher, Svorre Jordan Alexander, Møller Dina Leth, Heftdal Line Dam, Madsen Johannes Roth, Bayarri-Olmos Rafael, Hansen Cecilie Bo, Pries-Heje Mia Marie, Hasselbalch Rasmus Bo, Fogh Kamille, Armenteros Jose Juan Almagro, Hilsted Linda, Sørensen Erik, Lindegaard Birgitte, Browatzki Andrea, Biering-Sørensen Tor, Frikke-Schmidt Ruth, Ostrowski Sisse Rye, Iversen Kasper Karmark, Bundgaard Henning, Nielsen Susanne Dam, Garred Peter, Jensen Jens-Ulrik Stæhr
Аннотация
METHODS: Prospective cohort study including adults with chronic pulmonary diseases and healthcare personnel as controls (1:1). Blood was sampled at inclusion, 3 weeks, 2 and 6 months after first vaccination. We reported antibody concentrations as geometric means with 95% CI of receptor binding domain (RBD)-IgG and neutralising antibody index of inhibition of ACE-2/RBD interaction (%). A low responder was defined as neutralising index in the lowest quartile (primary outcome) or RBD-IgG <225 AU/mL plus neutralising index <25% (secondary outcome), measured at 2 months. We tested associations using Poisson regression.
RESULTS: We included 593 patients and 593 controls, 75% of all had neutralising index ≥97% at 2 months. For the primary outcome, 34.7% of patients (n=157/453) and 12.9% of controls (n=46/359) were low responders (p<0.0001). For the secondary outcome, 8.6% of patients (n=39/453) and 1.4% of controls (n=5/359) were low responders (p<0.001). Risk factors associated with low responder included increasing age (per decade, adjusted risk ratio (aRR) 1.17, 95% CI 1.03 to 1.32), Charlson Comorbidity Index (per point) (aRR 1.15, 95% CI 1.05 to 1.26), use of prednisolone (aRR 2.08, 95% CI 1.55 to 2.77) and other immunosuppressives (aRR 2.21, 95% CI 1.65 to 2.97).
DISCUSSION: Patients with chronic pulmonary diseases established functional humoral responses to vaccination, however lower than controls. Age, comorbidities and immunosuppression were associated with poor immunological responses.