Multiple sclerosis (Houndmills, Basingstoke, England) · 2015
The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients.
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Siritho Sasitorn, Sato Douglas K, Kaneko Kimihiko, Fujihara Kazuo, Prayoonwiwat Naraporn
Аннотация
BACKGROUND: Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients.
OBJECTIVES: To describe clinical phenotypes associated with anti-MOG.
METHODS: Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG.
RESULTS: Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment.
CONCLUSIONS: Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.
OBJECTIVES: To describe clinical phenotypes associated with anti-MOG.
METHODS: Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG.
RESULTS: Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment.
CONCLUSIONS: Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.
Предметные рубрики MeSH
Aquaporin 4AutoantibodiesBiomarkersDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaOptic NeuritisPredictive Value of TestsRecovery of FunctionRetrospective StudiesSerologic TestsThailandTreatment OutcomeVision, OcularYoung Adult