Nature clinical practice. Gastroenterology & hepatology · 2008
A case of fistulizing Crohn's disease and erythema nodosum managed with adalimumab.
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Quin Alissa, Kane Sunanda, Ulitsky Olga
Аннотация
BACKGROUND: A 20-year-old female presented to her gastroenterologist with fevers and right-labial pain and swelling. Painful erythematous nodules developed in her pretibial region soon after admission to a medical ward. She had a 10-year history of Crohn's colitis, perirectal abscesses and fistulizing disease, and had undergone a diverting ileostomy 16 months earlier; however, she was not on any medication for her Crohn's disease owing to her history of drug intolerance and side effects.
INVESTIGATIONS: Physical examination, laboratory investigations, examination under anesthesia, proctoscopy, MRI, and skin biopsy.
DIAGNOSIS: Active Crohn's disease with perianal fistula and sigmoid colitis, and erythema nodosum.
MANAGEMENT: Subcutaneous injections of adalimumab: an initial 160 mg dose, followed by 80 mg in week 2 and then 40 mg every other week. Antibiotics were also prescribed.
INVESTIGATIONS: Physical examination, laboratory investigations, examination under anesthesia, proctoscopy, MRI, and skin biopsy.
DIAGNOSIS: Active Crohn's disease with perianal fistula and sigmoid colitis, and erythema nodosum.
MANAGEMENT: Subcutaneous injections of adalimumab: an initial 160 mg dose, followed by 80 mg in week 2 and then 40 mg every other week. Antibiotics were also prescribed.