JACC. Cardiovascular imaging · 2010
Relationship between transmural extent of necrosis and quantitative recovery of regional strains after revascularization.
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Gerber Bernhard L, Darchis Julie, le Polain de Waroux Jean-Benoît, Legros Gabin, Pouleur Anne-Catherine, Vancraeynest David, Pasquet Agnès, Vanoverschelde Jean-Louis
Аннотация
OBJECTIVES: To better understand the quantitative relationship of recovery of regional and global dysfunction after revascularization in chronic infarcts with variable transmural extent of necrosis by delayed enhanced cardiac magnetic resonance.
BACKGROUND: Studies relating transmurality of delayed enhanced magnetic resonance to functional recovery in dysfunctional myocardium using semiquantitative Likert scales have demonstrated the intermediate likelihood (50% probability) of recovery of dysfunction in subendocardial scars.
METHODS: Forty-two patients with chronic left ventricular dysfunction due to coronary artery disease underwent tagged and delayed enhanced magnetic resonance before and 10 +/- 7 months after revascularization (coronary artery bypass graft: 35, percutaneous transluminal coronary angioplasty: 7). Left ventricular ejection fraction and regional mid-myocardial Eulerian radial thickening strain (Err) and mid-myocardial, subendocardial, and subepicardial Eulerian circumferential shortening strain (Ecc) strains were quantified in 16 segments per patient before and after revascularization and related to pre-operatively measured transmurality of necrosis.
RESULTS: At baseline, 256 of 672 segments were dysfunctional, having <2 SD (i.e., >-10%) mid-myocardial Ecc. The magnitude of recovery of mid-myocardial Ecc (r = -0.33, p < 0.01) was inversely correlated with transmurality of necrosis before revascularization. Segments with <25% necrosis improved mid-myocardial Ecc and Err. No significant improvement of mid-myocardial Ecc or Err occurred when transmurality was > or =25%. However, subendocardial Ecc improved up to 75% transmural necrosis. Receiver-operator characteristic analysis determined optimal sensitivity (54%) and specificity (82%) for normalization of mid-myocardial Ecc (to <-10% Ecc) at a cutoff value of > or =18% transmural necrosis. Improvement of left ventricular ejection fraction (from 35 +/- 15% to 40 +/- 7%, p < 0.001) was best predicted (67% sensitivity, 58% specificity) by the presence of <4.5 dysfunctional segments with <75% transmural necrosis.
CONCLUSIONS: The quantitative relationship between necrosis transmurality and improvement of regional and global dysfunction after revascularization is complex. Although improvement of recovery of regional mid-myocardial dysfunction after revascularization was observed only for scarring not exceeding 25% transmurality, global dysfunction significantly improved even when more extensive subendocardial scarring was revascularized.
BACKGROUND: Studies relating transmurality of delayed enhanced magnetic resonance to functional recovery in dysfunctional myocardium using semiquantitative Likert scales have demonstrated the intermediate likelihood (50% probability) of recovery of dysfunction in subendocardial scars.
METHODS: Forty-two patients with chronic left ventricular dysfunction due to coronary artery disease underwent tagged and delayed enhanced magnetic resonance before and 10 +/- 7 months after revascularization (coronary artery bypass graft: 35, percutaneous transluminal coronary angioplasty: 7). Left ventricular ejection fraction and regional mid-myocardial Eulerian radial thickening strain (Err) and mid-myocardial, subendocardial, and subepicardial Eulerian circumferential shortening strain (Ecc) strains were quantified in 16 segments per patient before and after revascularization and related to pre-operatively measured transmurality of necrosis.
RESULTS: At baseline, 256 of 672 segments were dysfunctional, having <2 SD (i.e., >-10%) mid-myocardial Ecc. The magnitude of recovery of mid-myocardial Ecc (r = -0.33, p < 0.01) was inversely correlated with transmurality of necrosis before revascularization. Segments with <25% necrosis improved mid-myocardial Ecc and Err. No significant improvement of mid-myocardial Ecc or Err occurred when transmurality was > or =25%. However, subendocardial Ecc improved up to 75% transmural necrosis. Receiver-operator characteristic analysis determined optimal sensitivity (54%) and specificity (82%) for normalization of mid-myocardial Ecc (to <-10% Ecc) at a cutoff value of > or =18% transmural necrosis. Improvement of left ventricular ejection fraction (from 35 +/- 15% to 40 +/- 7%, p < 0.001) was best predicted (67% sensitivity, 58% specificity) by the presence of <4.5 dysfunctional segments with <75% transmural necrosis.
CONCLUSIONS: The quantitative relationship between necrosis transmurality and improvement of regional and global dysfunction after revascularization is complex. Although improvement of recovery of regional mid-myocardial dysfunction after revascularization was observed only for scarring not exceeding 25% transmurality, global dysfunction significantly improved even when more extensive subendocardial scarring was revascularized.
Предметные рубрики MeSH
AgedAngioplasty, Balloon, CoronaryBelgiumChronic DiseaseCoronary Artery BypassFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMyocardial ContractionMyocardial InfarctionMyocardiumNecrosisPredictive Value of TestsProspective StudiesRecovery of FunctionStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, Left