American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011
Longevity candidate genes and their association with personality traits in the elderly.
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Luciano Michelle, Lopez Lorna M, de Moor Marleen H M, Harris Sarah E, Davies Gail, Nutile Teresa, Krueger Robert F, Esko Tõnu, Schlessinger David, Toshiko Tanaka, Derringer Jaime L, Realo Anu, Hansell Narelle K, Pergadia Michele L, Pesonen Anu-Katriina, Sanna Serena, Terracciano Antonio, Madden Pamela A F, Penninx Brenda, Spinhoven Philip, Hartman Catherina A, Oostra Ben A, Janssens A Cecile J W, Eriksson Johan G, Starr John M, Cannas Alessandra, Ferrucci Luigi, Metspalu Andres, Wright Margeret J, Heath Andrew C, van Duijn Cornelia M, Bierut Laura J, Raikkonen Katri, Martin Nicholas G, Ciullo Marina, Rujescu Dan, Boomsma Dorret I, Deary Ian J
Аннотация
Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.