The Predictive Value of MiR-205-5p for Abdominal Adhesion and Postpartum Complications in Women with Scarred Uterus.

MicroRNA (miRNA), as a molecule with regulatory functions, has become a research hotspot for diagnosis or prognosis in various diseases. This study investigates the predictive value of miR-205-5p concerning abdominal adhesions and postpartum complications in women undergoing secondary cesarean sections with a scarred uterus. Before the second cesarean section, the condition of the scar was evaluated using the Patient and Observer Scar Assessment Scale (POSAS). The serum levels of miR-205-5p were quantified through RT-qPCR, and the pregnant women were divided into the high-expression group and the low-expression group based on the average level of miR-205-5p. Subsequent analyses compared the abdominal scar scores, pelvic floor muscle fiber strength, incidence of abdominal adhesions, and the rate of postpartum complications. The predictive value of miR-205-5p for abdominal adhesions and complications was assessed via receiver operating characteristic (ROC) curve. The findings revealed a negative correlation between miR-205-5p levels and POSAS scores. Furthermore, the incidence of abdominal adhesions and postpartum complications was significantly lower in the high-expression group compared to their low-expression counterparts. The area under the curve (AUC) for predicting abdominal adhesions and postpartum complications using miR-205-5p was determined to be 0.822 and 0.831, respectively. Notably, no significant differences were observed in pelvic floor muscle function between the two groups. In conclusion, this study posits that miR-205-5p holds substantial promise as a predictive biomarker for abdominal adhesions and postpartum complications in women with a scarred uterus.