Journal of equine veterinary science · 2026
Influence of housing and fecal egg count on cytokine profiles (IL-4 and IL-13) in equines.
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Yalavarthi G, Sabbinen H, Kosuri P, Amalaradjou M, Govoni K, Nadeau J
Аннотация
BACKGROUND: Strongyles are parasitic roundworms that cause significant gastrointestinal infections in equines, primarily through contact with infected soil. Worldwide, strongylosis affects nearly 90% of horse populations.
AIMS/OBJECTIVE: The objectives of our study were to determine if there was a relationship between fecal egg count (FEC) and housing types on interleukin IL-4 and IL-13.
METHODOLOGY: Horses (N = 25) were separated into two groups based on housing conditions: pasture (housed on pasture 24/7; PS, N = 13) and semi-intensive (housed in stalls with turnout overnight; SI, N = 12). Within each housing group, the horses were further classified into two subgroups (high or low) according to their FEC levels. The McMaster method was used to perform FEC. Blood-derived plasma samples were used to quantify ILs by ELISA. Data were analyzed using two-way ANOVA to assess housing and FEC effects.
RESULTS: Increased IL-4 and IL-13 levels were detected in high FEC horses compared with low FEC horses (P < 0.05; 95% CI: 60.39-115.3 pg/mL and 505.3-808.9 pg/mL). Between housing types, IL-4 levels were increased in PS housing (P < 0.05; 95% CI: -94.01 to -12.43 pg/mL), and IL-13 levels were increased in horses in SI housing (P < 0.05; 95% CI: 39.67-617.0 pg/mL). There was no interaction between housing and FEC (P > 0.05; 95% CI: -592.0-401.7 pg/mL and -69.03-49.33 pg/mL).
CONCLUSION: There were elevated concentrations of IL-4 and IL-13 in horses with high FEC; PS housing increased IL-4 and SI housing increased IL-13. There was no interaction between housing and FEC.
AIMS/OBJECTIVE: The objectives of our study were to determine if there was a relationship between fecal egg count (FEC) and housing types on interleukin IL-4 and IL-13.
METHODOLOGY: Horses (N = 25) were separated into two groups based on housing conditions: pasture (housed on pasture 24/7; PS, N = 13) and semi-intensive (housed in stalls with turnout overnight; SI, N = 12). Within each housing group, the horses were further classified into two subgroups (high or low) according to their FEC levels. The McMaster method was used to perform FEC. Blood-derived plasma samples were used to quantify ILs by ELISA. Data were analyzed using two-way ANOVA to assess housing and FEC effects.
RESULTS: Increased IL-4 and IL-13 levels were detected in high FEC horses compared with low FEC horses (P < 0.05; 95% CI: 60.39-115.3 pg/mL and 505.3-808.9 pg/mL). Between housing types, IL-4 levels were increased in PS housing (P < 0.05; 95% CI: -94.01 to -12.43 pg/mL), and IL-13 levels were increased in horses in SI housing (P < 0.05; 95% CI: 39.67-617.0 pg/mL). There was no interaction between housing and FEC (P > 0.05; 95% CI: -592.0-401.7 pg/mL and -69.03-49.33 pg/mL).
CONCLUSION: There were elevated concentrations of IL-4 and IL-13 in horses with high FEC; PS housing increased IL-4 and SI housing increased IL-13. There was no interaction between housing and FEC.