Journal of ethnopharmacology · 2025
Chemical compounds from Allii Tuberosi Semen exhibiting anti-fibrotic effects on hepatic stellate cells.
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Zhao Rihong, Liu Xiping, Liu Jinjin, Wang Hao, Cui Yuzi, Yu Rui, Jin Tiantian, Wang Shuyun, Qin Xinyu, Wang Meijun, Ji Li, Wang Tianxiao, Jalsrai Aldarmaa, Cong Yue
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis involves changes in tissue structure and extracellular matrix composition due to multiple chronic liver diseases. Hepatic stellate cells (HSCs) play a crucial role in the development of liver fibrosis. Allii Tuberosi Semen, derived from the mature seed of Allium tuberosum Rottl.ex Spreng. (Liliaceae), is a traditional Chinese medicine known for its numerous bioactive properties, including hepatoprotective effects, sexual function improvement, immunity enhancement, anti-oxidation, and anti-microbial activities.
AIM OF THE STUDY: This study aimed to identify effective ingredients in Allii Tuberosi Semen with anti-liver fibrosis properties.
MATERIALS AND METHODS: Extensive spectroscopic analysis was performed to identify the structures of the unreported compounds. Furthermore, these compounds were evaluated for anti-fibrotic effects on HSCs and the underlying molecular mechanisms.
RESULTS: Five new steroidal saponins, compounds 1-5, were isolated from Allii Tuberosi Semen, together with eight known compounds. Additionally, the carbon and hydrogen signals of compound 6 were assigned for the first time. These compounds significantly suppressed TGF-β1-induced HSCs activation via effectively reducing cell viability and migration while increasing the apoptosis rate. Further investigation was found that compound 8 inhibit the TGF-β1/Smad and PI3K/Akt pathways, increasing Bax/Bcl-2 ratio.
CONCLUSIONS: The results indicate that compounds 1-12 are effective inhibitors of liver fibrosis, making them promising agents for treating hepatic fibrosis.
AIM OF THE STUDY: This study aimed to identify effective ingredients in Allii Tuberosi Semen with anti-liver fibrosis properties.
MATERIALS AND METHODS: Extensive spectroscopic analysis was performed to identify the structures of the unreported compounds. Furthermore, these compounds were evaluated for anti-fibrotic effects on HSCs and the underlying molecular mechanisms.
RESULTS: Five new steroidal saponins, compounds 1-5, were isolated from Allii Tuberosi Semen, together with eight known compounds. Additionally, the carbon and hydrogen signals of compound 6 were assigned for the first time. These compounds significantly suppressed TGF-β1-induced HSCs activation via effectively reducing cell viability and migration while increasing the apoptosis rate. Further investigation was found that compound 8 inhibit the TGF-β1/Smad and PI3K/Akt pathways, increasing Bax/Bcl-2 ratio.
CONCLUSIONS: The results indicate that compounds 1-12 are effective inhibitors of liver fibrosis, making them promising agents for treating hepatic fibrosis.