Obstetrics and gynecology · 1993
Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes.
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Gemer O, Segal S, Segal O, Zohav E, Sassoon E
Аннотация
BACKGROUND: Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy.
CASE: A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.
CONCLUSION: This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.
CASE: A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.
CONCLUSION: This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.