Infectious diseases of poverty · 2026
First imported case of New World leishmaniasis in Romania: diagnostic and therapeutic challenges in a non-endemic country.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mihalca Andrei Daniel, Mitrea Ioana Bianca, Lupșe Mihaela Sorina, Ionică Angela Monica, Baneth Gad, Nachum-Biala Yaarit, Kumar Jaideep, Taulescu Marian, Dantas-Torres Filipe, de Macedo Felipe Marinho Rocha, Șenilă Simona Corina
Аннотация
BACKGROUND: Leishmaniasis is a vector-borne protozoan disease with cutaneous, mucocutaneous, and visceral forms. In Europe, most cases involve Old World species, while imported New World infections are rare. We report the first imported human case of New World cutaneous leishmaniasis in Romania.
CASE PRESENTATION: A 25-year-old woman developed progressive ulcerative lesions on her left arm after travel to Panama and Costa Rica. Initial biopsy revealed granulomatous inflammation without identifying the agent. A second biopsy detected amastigotes within macrophages, and molecular analyses (ITS1 sequencing, hsp70 phylogenetic analysis) identified Leishmania panamensis. The patient received oral miltefosine for 28 days, with gradual improvement and complete healing with atrophic scars. No relapse occurred 473 days post-treatment.
CONCLUSIONS: This case highlights diagnostic challenges in non-endemic regions, emphasizing the need to raise clinical awareness and improve access to molecular tools for prompt recognition and management of imported leishmaniasis in Eastern Europe.
CASE PRESENTATION: A 25-year-old woman developed progressive ulcerative lesions on her left arm after travel to Panama and Costa Rica. Initial biopsy revealed granulomatous inflammation without identifying the agent. A second biopsy detected amastigotes within macrophages, and molecular analyses (ITS1 sequencing, hsp70 phylogenetic analysis) identified Leishmania panamensis. The patient received oral miltefosine for 28 days, with gradual improvement and complete healing with atrophic scars. No relapse occurred 473 days post-treatment.
CONCLUSIONS: This case highlights diagnostic challenges in non-endemic regions, emphasizing the need to raise clinical awareness and improve access to molecular tools for prompt recognition and management of imported leishmaniasis in Eastern Europe.