Ginekologia polska · 2026
Serum BMP8B levels in women with polycystic ovary syndrome: a case-control study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ren Xiao-Pang, Liu Man, Hao Wan-Jiao, Xue Hui-Ling, Li Ye, Wei Jun-Xiu, Song Jie
Аннотация
OBJECTIVES: To investigate serum brown adipokine BMP8b levels in polycystic ovary syndrome (PCOS) and their association with metabolic parameters.
MATERIAL AND METHODS: The present cross-sectional analysis enrolled 80 PCOS-diagnosed women alongside 40 matched controls. Serum levels of BMP8b, lipids, glucose metabolism, and reproductive hormones were assayed. Insulin resistance was assessed by HOMA-IR.
RESULTS: Patients with PCOS exhibited significantly lower serum BMP8b levels compared to controls (43.11 ± 13.09 vs 106.45 ± 52.32, p < 0.001). In the PCOS group, BMP8b showed significant negative correlations with both BMI (r = -0.240, p < 0.05) and HOMA-IR (r = -0.246, p < 0.05), while in the control group, BMP8b was negatively correlated with TG (r = -0.436, p < 0.05). Notably, pooled analysis of all subjects revealed a strong inverse correlation between BMP8b and total testosterone (T) (r = -0.468, p < 0.001).
CONCLUSIONS: Reduced BMP8b in PCOS correlates with metabolic dysfunction, suggesting brown adipose tissue as a potential therapeutic target.
MATERIAL AND METHODS: The present cross-sectional analysis enrolled 80 PCOS-diagnosed women alongside 40 matched controls. Serum levels of BMP8b, lipids, glucose metabolism, and reproductive hormones were assayed. Insulin resistance was assessed by HOMA-IR.
RESULTS: Patients with PCOS exhibited significantly lower serum BMP8b levels compared to controls (43.11 ± 13.09 vs 106.45 ± 52.32, p < 0.001). In the PCOS group, BMP8b showed significant negative correlations with both BMI (r = -0.240, p < 0.05) and HOMA-IR (r = -0.246, p < 0.05), while in the control group, BMP8b was negatively correlated with TG (r = -0.436, p < 0.05). Notably, pooled analysis of all subjects revealed a strong inverse correlation between BMP8b and total testosterone (T) (r = -0.468, p < 0.001).
CONCLUSIONS: Reduced BMP8b in PCOS correlates with metabolic dysfunction, suggesting brown adipose tissue as a potential therapeutic target.