Journal of dentistry · 2026
In vitro assessment of the antibacterial properties of novel chemomechanical caries removal agents and their impact on bonding performance to resin composite restorations.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Al-Badri Huda, Al-Taee Lamis A, Hashem Danya, Ahmed Khaled E, Banerjee Avijit, Al-Shammaree Shatha A
Аннотация
OBJECTIVES: To assess the antibacterial efficacy of novel bromelain-containing chemomechanical caries removal (CMCR) agents and their effect on the bonding strength of residual dentine to an adhesive resin composite restoration.
METHODS: The antibacterial efficacy of three formulated CMCR gels, comprising 30 % bromelain (F1), 30 % bromelain with 0.1 wt.% chloramine-T (F2), and 30 % bromelain with 1.5 % chlorhexidine (F3), was evaluated in comparison to Brix 3000, specifically against Streptococcus mutans and Lactobacillus acidophilus species. A total of 120 extracted permanent molars exhibiting natural carious lesions were randomly allocated into six groups based on excavation techniques; hand excavation, rotary excavation, Brix 3000, F1, F2, and F3. The microshear bond strength (µSBS) of the residual dentine to resin composite was assessed after two-time intervals. The morphological assessment was conducted using scanning electron microscopy (SEM).
RESULTS: F3 demonstrated the most pronounced statistically significant antimicrobial efficacy against both bacterial species (p < 0.001), as well as the highest statistically significant immediate µSBS to the residual dentine (p < 0.001). In contrast, F2 exhibited the highest µSBS mean value post aging (p < 0.001), along with the greatest percentage of mixed and cohesive failures. This was accompanied by the presence of a well-integrated hybrid layer and numerous elongated resin tags within the residual dentine.
CONCLUSION: The novel bromelain-based CMCR gels, particularly when combined with chlorhexidine, demonstrated a remarkable antimicrobial efficiency. In contrast, the formulation containing chloramine-T exhibited superior prolonged bonding performance.
CLINICAL SIGNIFICANCE: These novel formulations present a promising strategy for caries management and enhance the longevity of adhesive restorations.
METHODS: The antibacterial efficacy of three formulated CMCR gels, comprising 30 % bromelain (F1), 30 % bromelain with 0.1 wt.% chloramine-T (F2), and 30 % bromelain with 1.5 % chlorhexidine (F3), was evaluated in comparison to Brix 3000, specifically against Streptococcus mutans and Lactobacillus acidophilus species. A total of 120 extracted permanent molars exhibiting natural carious lesions were randomly allocated into six groups based on excavation techniques; hand excavation, rotary excavation, Brix 3000, F1, F2, and F3. The microshear bond strength (µSBS) of the residual dentine to resin composite was assessed after two-time intervals. The morphological assessment was conducted using scanning electron microscopy (SEM).
RESULTS: F3 demonstrated the most pronounced statistically significant antimicrobial efficacy against both bacterial species (p < 0.001), as well as the highest statistically significant immediate µSBS to the residual dentine (p < 0.001). In contrast, F2 exhibited the highest µSBS mean value post aging (p < 0.001), along with the greatest percentage of mixed and cohesive failures. This was accompanied by the presence of a well-integrated hybrid layer and numerous elongated resin tags within the residual dentine.
CONCLUSION: The novel bromelain-based CMCR gels, particularly when combined with chlorhexidine, demonstrated a remarkable antimicrobial efficiency. In contrast, the formulation containing chloramine-T exhibited superior prolonged bonding performance.
CLINICAL SIGNIFICANCE: These novel formulations present a promising strategy for caries management and enhance the longevity of adhesive restorations.
Предметные рубрики MeSH
HumansStreptococcus mutansComposite ResinsChlorhexidineAnti-Bacterial AgentsDental CariesDental BondingLactobacillus acidophilusMicroscopy, Electron, ScanningDentinChloraminesBromelainsDental Restoration, PermanentMaterials TestingShear StrengthDental Cavity PreparationDental MaterialsTime FactorsResin CementsMolarDentin-Bonding AgentsTosyl Compounds