A glass ionomer for reconstructive surgery. Ionogran--an ionomeric micro implant. A biological evaluation.

A porous glass-ionomer (Ionogran) was evaluated and compared to hydroxyapatite Interpore 200. In an in-vivo screening test procedure, microfilter diffusion chambers embedded on the tibial surfaces of adult baboons were used to evaluate cell survival, cell regeneration and cell differentiation. In a bulk testing procedure a standardized bone core was removed from the tibia through the knee joint and the material exposed to the defense mechanisms of the system. Both materials were found to be biocompatible, non-toxic and did not inhibit cell proliferation in the enclosed environment of diffusion chambers. Histological response and cell arrangement within the chambers containing Ionogran were similar to that of the controls with cancellous bone only. Highly specialized haemopoietic tissues were in direct contact with the Ionogran. In the presence of hydroxyapatite new bone was actively formed. Haemopoietic elements were never found in contact with the hydroxyapatite. In the bulk testing procedure, the general histological appearance was that of a reactive tissue response to a low grade persistent stimulation coupled to surface degradation products. The Ionogran was found to be stable, osteo-conductive and promoted osteoid formation when in contact with bone. From a clinical point of view the material could serve as a permanent scaffold, maintaining form, and will be of value in bone reconstructive procedures.