High titers of infectious SARS-CoV-2 in corpses of patients with COVID-19.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Saitoh Hisako, Sakai-Tagawa Yuko, Nagasawa Sayaka, Torimitsu Suguru, Kubota Kazumi, Hirata Yuichiro, Iwatsuki-Horimoto Kiyoko, Motomura Ayumi, Ishii Namiko, Okaba Keisuke, Horioka Kie, Abe Hiroyuki, Ikemura Masako, Rokutan Hirofumi, Hinata Munetoshi, Iwasaki Akiko, Yasunaga Yoichi, Nakajima Makoto, Yamaguchi Rutsuko, Tsuneya Shigeki, Kira Kei, Kobayashi Susumu, Inokuchi Go, Chiba Fumiko, Hoshioka Yumi, Mori Aika, Yamamoto Isao, Nakagawa Kimiko, Katano Harutaka, Iida Shun, Suzuki Tadaki, Akitomi Shinji, Hasegawa Iwao, Ushiku Tetsuo, Yajima Daisuke, Iwase Hirotaro, Makino Yohsuke, Kawaoka Yoshihiro
Аннотация
METHODS: We collected 11 nasopharyngeal swabs and 19 lung tissue specimens from 11 autopsy cases with COVID-19 in 2021. We then investigated the viral genomic copy number by real-time reverse transcription-polymerase chain reaction and infectious titers by cell culture and virus isolation.
RESULTS: Infectious virus was present in six of 11 (55%) cases, four of 11 (36%) nasopharyngeal swabs, and nine of 19 (47%) lung specimens. The virus titers ranged from 6.00E + 01 plaque-forming units/ml to 2.09E + 06 plaque-forming units/g. In all cases in which an infectious virus was found, the time from death to discovery was within 1 day and the longest postmortem interval was 13 days.
CONCLUSION: The corpses of patients with COVID-19 may have high titers of infectious virus after a long postmortem interval (up to 13 days). Therefore, appropriate infection control measures must be taken when handling corpses.