The American journal of clinical nutrition · 2025
Plasma chylomicron-rich lipidomic and fatty acid profile following a meat or analog meal in healthy males: A randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Pham Toan, Morton Lillian, Gillies Nicola, Bermingham Emma, Knowles Scott, Cameron-Smith David, Braakhuis Andrea J
Аннотация
BACKGROUND: The composition of a meal impacts the digestion and absorption of dietary fats, potentially affecting their role in cardiovascular and chronic disease risk.
OBJECTIVES: To compare the fatty acid concentrations, including long-chain ω-3 fatty acids, the lipidome, and lipids in response to a meal containing grain-fed beef, pasture-fed beef, lamb, or Beyond Burger [plant-based meat alternatives (PBMA)].
METHODS: We conducted a randomized crossover trial where healthy males (n = 27) consumed a standardized burrito-style meal containing meat or an alternative matched for protein and carbohydrate content on 4 separate occasions, with a minimum washout period of 1-wk. Blood samples were collected before the meal and hourly for 4 h after the meal. The changes in the fatty acid distribution, the lipidome of the chylomicron-rich fraction, and plasma lipids were analyzed.
RESULTS: Linear mixed modeling and mixed effect analysis of variance showed significant changes in the fatty acid postprandial response following all meals (P < 0.05) and subtle differences between meal types. Significant lipidomic features were predominantly triglyceride for time (89 of 223) and meal (63 of 66). Meat meals had higher lysophosphatidylcholines in the chylomicrons [χ2(3) = 6.00, P = 0.042; W = 0.074, 95% confidence interval (CI): 0.024, 1.030]. The grain beef and lamb showed a significantly lower triglyceride response in plasma compared to PBMA (grain: -0.346; 95% CI: -0.692, -0.0004; lamb: -0.458; 95% CI: -0.880, -0.034).
CONCLUSIONS: There are subtle differences in the lipid response to beef, lamb, and PMBA-containing meals. This trial was registered at clinicaltrials.gov as NCT04545398.
OBJECTIVES: To compare the fatty acid concentrations, including long-chain ω-3 fatty acids, the lipidome, and lipids in response to a meal containing grain-fed beef, pasture-fed beef, lamb, or Beyond Burger [plant-based meat alternatives (PBMA)].
METHODS: We conducted a randomized crossover trial where healthy males (n = 27) consumed a standardized burrito-style meal containing meat or an alternative matched for protein and carbohydrate content on 4 separate occasions, with a minimum washout period of 1-wk. Blood samples were collected before the meal and hourly for 4 h after the meal. The changes in the fatty acid distribution, the lipidome of the chylomicron-rich fraction, and plasma lipids were analyzed.
RESULTS: Linear mixed modeling and mixed effect analysis of variance showed significant changes in the fatty acid postprandial response following all meals (P < 0.05) and subtle differences between meal types. Significant lipidomic features were predominantly triglyceride for time (89 of 223) and meal (63 of 66). Meat meals had higher lysophosphatidylcholines in the chylomicrons [χ2(3) = 6.00, P = 0.042; W = 0.074, 95% confidence interval (CI): 0.024, 1.030]. The grain beef and lamb showed a significantly lower triglyceride response in plasma compared to PBMA (grain: -0.346; 95% CI: -0.692, -0.0004; lamb: -0.458; 95% CI: -0.880, -0.034).
CONCLUSIONS: There are subtle differences in the lipid response to beef, lamb, and PMBA-containing meals. This trial was registered at clinicaltrials.gov as NCT04545398.