International forum of allergy & rhinology · 2019
Association between chronic rhinosinusitis and osteoporosis: a case-control study using a national sample cohort.
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Choi Hyo Geun, Kong Il Gyu
Аннотация
BACKGROUND: The purpose of this study was to further clarify the relationship between chronic rhinosinusitis (CRS) and osteoporosis in a Korean population.
METHODS: The Korean National Health Insurance Service-National Sample Cohort, with subjects ≥50 years old, was assessed for the time period 2002-2013. In total, 68,459 osteoporosis participants were matched with 68,459 control participants at a ratio of 1:1 with respect to age, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of CRS with/without nasal polyp in the osteoporosis and control groups. CRS and osteoporosis were included using codes from the International Classification of Diseases-tenth edition and claim codes. Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. The 95% confidence intervals (CIs) were then calculated. Subgroup analyses were performed according to age and sex.
RESULTS: The rate of CRS with/without nasal polyp was higher in the osteoporosis group (3.0% [2078 of 68,459]) compared with the control group (2.0% [1344 of 68,459]) (p < 0.001). The adjusted OR of CRS with/without nasal polyp was 1.47 (95% CI, 1.37-1.58; p < 0.001) in the osteoporosis group. The results of the subgroup analyses were consistent.
CONCLUSION: The ORs of CRS were increased in osteoporosis participants. This relation was consistent in all age and sex groups.
METHODS: The Korean National Health Insurance Service-National Sample Cohort, with subjects ≥50 years old, was assessed for the time period 2002-2013. In total, 68,459 osteoporosis participants were matched with 68,459 control participants at a ratio of 1:1 with respect to age, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of CRS with/without nasal polyp in the osteoporosis and control groups. CRS and osteoporosis were included using codes from the International Classification of Diseases-tenth edition and claim codes. Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. The 95% confidence intervals (CIs) were then calculated. Subgroup analyses were performed according to age and sex.
RESULTS: The rate of CRS with/without nasal polyp was higher in the osteoporosis group (3.0% [2078 of 68,459]) compared with the control group (2.0% [1344 of 68,459]) (p < 0.001). The adjusted OR of CRS with/without nasal polyp was 1.47 (95% CI, 1.37-1.58; p < 0.001) in the osteoporosis group. The results of the subgroup analyses were consistent.
CONCLUSION: The ORs of CRS were increased in osteoporosis participants. This relation was consistent in all age and sex groups.