PREVAILING CLINICO-PATHOGENETIC PARAMETERS IN PATIENTS WITH POLYPOUS RHINOSINUSITIS.

Aim - Improvement of polypous rhinosinusitis anti-relapse treatment efficacy by distinguishing of the core meaningful factors of the disease's development. The study included 300 patients with polypous rhinosinusitis aged 18-77 years. Comprehensive evaluation of the data is done by means of factor analysis by the method of the main components with subsequent varimax-rotation of the factor axes. The critical value of p-level was 0.05. As a result of the factorial analysis, 6 main factors were identified, the joint action of which explains 53.72% of the variability of indicators for the polypous rhinosinusitis. The factor analysis allowed to distinguish the groups of indicators and estimate the specific weight of individual pathogenetic factors in the development of polypous rhinosinusitis, which might be conditionally combined under the general names of «clinic-immune», «clinic-pathomorphological», «immunoregulatory», «clinical-microbiological», «violation local protection»,»epidemiological and demographic «factors. The effect of two of the most powerful factors («clinical-immune» and «clinic-pathomorphological factor») is explained by 46.47% of the variability of indicators. Factor estimates for the most potent «clinically-immune-causative factor» with a high degree of reliability distinguished groups of patients with the first identified polypous rhinosinusitis and its relapse. Perspectives of further investigations are related to mathematical modeling of the pathological process using artificial neural networks.