Eye (London, England) · 2011
Corneal nerve alterations in acute Acanthamoeba and fungal keratitis: an in vivo confocal microscopy study.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kurbanyan K, Hoesl L M, Schrems W A, Hamrah P
Аннотация
PURPOSE: To study sub-basal corneal nerve alterations in patients with acute Acanthamoeba keratitis (AK) and fungal keratitis (FK), using laser in vivo confocal microscopy (IVCM).
METHODS: A retrospective analysis of IVCM (Heidelberg Retina Tomograph 3/Rostock Cornea Module) images of 10 AK corneas and 4 FK corneas was performed, and the results compared with those of 10 normal and 12 acute herpetic keratitis (HK) corneas. Sub-basal corneal nerves were analyzed with respect to total number of nerves, main nerve trunks, branching pattern and total length of nerves per image, as well as tortuosity. For each variable, results for three frames were averaged and analyzed using analysis of variance.
RESULTS: Total corneal nerve length was significantly (P < 0.0001) reduced in patients with AK (193.4 ± 124.5 μm) and FK (268.6 ± 257.4 μm) when compared with normal controls (3811.84 ± 911.4 μm). Total nerve counts in patients with AK (3.9 ± 1.2) and FK (3.6 ± 3.2) were significantly (P < 0.0001) decreased in comparison with normal controls (24.7 ± 5.5). The number of main nerve trunks and nerve branching was found to be significantly lower in AK and FK corneas, when compared with controls. There was a statistically significant decrease in the above parameters when compared with HK controls.
CONCLUSIONS: The sub-basal corneal nerve plexus is significantly diminished in eyes with AK and FK, as demonstrated by IVCM. These results are more profound than previously reported findings of a diminished nerve plexus in HK.
METHODS: A retrospective analysis of IVCM (Heidelberg Retina Tomograph 3/Rostock Cornea Module) images of 10 AK corneas and 4 FK corneas was performed, and the results compared with those of 10 normal and 12 acute herpetic keratitis (HK) corneas. Sub-basal corneal nerves were analyzed with respect to total number of nerves, main nerve trunks, branching pattern and total length of nerves per image, as well as tortuosity. For each variable, results for three frames were averaged and analyzed using analysis of variance.
RESULTS: Total corneal nerve length was significantly (P < 0.0001) reduced in patients with AK (193.4 ± 124.5 μm) and FK (268.6 ± 257.4 μm) when compared with normal controls (3811.84 ± 911.4 μm). Total nerve counts in patients with AK (3.9 ± 1.2) and FK (3.6 ± 3.2) were significantly (P < 0.0001) decreased in comparison with normal controls (24.7 ± 5.5). The number of main nerve trunks and nerve branching was found to be significantly lower in AK and FK corneas, when compared with controls. There was a statistically significant decrease in the above parameters when compared with HK controls.
CONCLUSIONS: The sub-basal corneal nerve plexus is significantly diminished in eyes with AK and FK, as demonstrated by IVCM. These results are more profound than previously reported findings of a diminished nerve plexus in HK.