Investigative ophthalmology & visual science · 2011
A prototype antifungal contact lens.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ciolino Joseph B, Hudson Sarah P, Mobbs Ashley N, Hoare Todd R, Iwata Naomi G, Fink Gerald R, Kohane Daniel S
Аннотация
PURPOSE: To design a contact lens to treat and prevent fungal ocular infections.
METHODS: Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.
RESULTS: Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.
CONCLUSIONS: An econazole-eluting contact lens could be used as a treatment for fungal ocular infections.
METHODS: Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.
RESULTS: Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.
CONCLUSIONS: An econazole-eluting contact lens could be used as a treatment for fungal ocular infections.
Предметные рубрики MeSH
Antifungal AgentsBiocompatible MaterialsCandida albicansContact Lenses, HydrophilicCorneal UlcerDesiccationDrug Delivery SystemsEconazoleEquipment DesignLactic AcidMicroscopy, Electron, ScanningPolyglycolic AcidPolyhydroxyethyl MethacrylatePolylactic Acid-Polyglycolic Acid CopolymerSpectrum Analysis, Raman