Medical Therapies of Cushing's Disease-Part 2.

Cushing's disease (CD) is an endogenous hypercortisolism state caused by an adrenocorticotropic hormone (ACTH) secreting pituitary adenoma. Medical therapy is an important second-line treatment for CD. New pharmacologic agents for the treatment of patients with CD are under development. New possible intervention targets include various receptors and pathways in the corticotroph tumor, the hormone ACTH, and its receptor and enzymes involved in cortisone metabolism. This part of the article will focus on tailoring pharmacologic therapy according to patient specific characteristics, long-term medical therapy and development of new drugs for CD.