Treatment tolerability associated with carboplatin dose based on actual versus adjusted body weight in patients with a body mass index ≥25 kg/m2 with advanced ovarian cancer.

OBJECTIVE

We sought to describe the treatment tolerability of carboplatin when dosed based on actual versus adjusted body weight in patients with a body mass index (BMI) ≥25 kg/m2 who had advanced ovarian cancer.

METHODS

In this single-center, retrospective, descriptive analysis, we included patients with advanced-stage epithelial ovarian cancer who had a BMI ≥25 kg/m2 and received first-line treatment with carboplatin and paclitaxel. We compared patients who received carboplatin dosed based on actual body weight with those whose dosing was based on adjusted body weight. The primary endpoint was the composite incidence of treatment modifications.

RESULTS

A total of 101 patients were included in this study: 61 in the actual body weight-based dosing group and 40 in the adjusted body weight-based dosing group. There was no significant difference in the incidence of treatment modifications between groups (73.8% vs 57.5%, p = .09). Dose reductions of carboplatin and treatment delays were more common in the actual body weight-based dosing group (39.3% vs 15.0%, p = .009) and (32.8 vs 5.0%, p = .001), respectively. Grade ≥3 neutropenia (19.7% vs 12.5%) and thrombocytopenia (13.1% vs 0.0%) were higher in the actual body weight group. More patients in the adjusted body weight-based dosing group initiated next-line therapy (55% vs 26.2%, p = .004). Median time to next treatment or death was not reached in the actual body weight-based dosing group but was 19.3 months (95% CI 12.4 to 24.0) in the adjusted body weight-based dosing group (HR 0.32, 95% CI 0.18 to 0.58, p = .0001). Death from any cause was lower in the actual body weight group (19.7% vs 60.0%, HR 0.35, 95% CI 0.18 to 0.71, p = .003).

CONCLUSIONS

Dosing carboplatin using adjusted body weight in patients with a BMI ≥25 kg/m2 may lead to fewer carboplatin dose reductions and treatment delays.