Radiography (London, England : 1995) · 2025
Novel quantitative parameters of lymphatic contrast-enhanced ultrasound for breast cancer-related lymphoedema: Correlating with clinical staging.
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Liu Z J, Zeng Z S, Fu P, Wang J L, Zhu J, Liu Z R, Zhang L L
Аннотация
INTRODUCTION: This study aimed to investigate the correlation between contrast-enhanced ultrasound (CEUS) characteristics of lymphatic vessels in affected limbs and International Society of Lymphology (ISL) clinical staging in patients with breast cancer-related lymphoedema (BCRL). Additionally, we sought to evaluate the validity of CEUS parameters in assessing lymphatic function.
METHODS: Clinical and lymphatic CEUS data of 42 patients with BCRL were collected prospectively. The morphology of collecting lymphatic vessels (CLVs) was classified into five types: beaded, linear, tortuous-and-dilated, unevenly dilated, and blind-ended. The correlations between ISL clinical stages in BCRL patients and the following parameters were recorded: internal diameter of CLVs, the number of visualised CLVs, and the number of CLVs reaching above the elbow (CLV-RAE). Additionally, differences in these lymphatic parameters with different ISL stages were compared.
RESULTS: A total of 346 CLVs were visualised in 42 BCRL patients, of which 246 CLVs were visualised above the elbow joint. The percentage of visualised CLV-RAE showed a stronger association with disease progression (r = -0.74, p < 0.05). The internal diameter of the thickest visualised CLVs demonstrated a more pronounced correlation (r = 0.69, p < 0.05). Morphological features of the CLVs showed significant staging correlations.
CONCLUSION: CEUS could accurately assess the structural and functional status of lymphatic vessels by quantitatively analysing critical parameters, including the number of CLVs, internal diameter, and imaging pattern.
IMPLICATIONS FOR PRACTICE: This study confirms the validity of CEUS parameters in assessing lymphatic vessel function and is expected to construct a quantitative assessment system for BCRL lymphatic function with the support of CEUS.
METHODS: Clinical and lymphatic CEUS data of 42 patients with BCRL were collected prospectively. The morphology of collecting lymphatic vessels (CLVs) was classified into five types: beaded, linear, tortuous-and-dilated, unevenly dilated, and blind-ended. The correlations between ISL clinical stages in BCRL patients and the following parameters were recorded: internal diameter of CLVs, the number of visualised CLVs, and the number of CLVs reaching above the elbow (CLV-RAE). Additionally, differences in these lymphatic parameters with different ISL stages were compared.
RESULTS: A total of 346 CLVs were visualised in 42 BCRL patients, of which 246 CLVs were visualised above the elbow joint. The percentage of visualised CLV-RAE showed a stronger association with disease progression (r = -0.74, p < 0.05). The internal diameter of the thickest visualised CLVs demonstrated a more pronounced correlation (r = 0.69, p < 0.05). Morphological features of the CLVs showed significant staging correlations.
CONCLUSION: CEUS could accurately assess the structural and functional status of lymphatic vessels by quantitatively analysing critical parameters, including the number of CLVs, internal diameter, and imaging pattern.
IMPLICATIONS FOR PRACTICE: This study confirms the validity of CEUS parameters in assessing lymphatic vessel function and is expected to construct a quantitative assessment system for BCRL lymphatic function with the support of CEUS.