[A retrospective cohort study on survival status of AIDS patients among 15 or above-year-olds in Henan province, from 2008 to 2015].

Objective

To explore the survival status and affecting factors among patients diagnosed as AIDS, in Henan province.

Methods

Database of AIDS patients were downloaded from the China information system for disease prevention and control-AIDS with a retrospective study conducted. Inclusion criteria on patients would involve those diagnosed between 2008 and 2015, aged 15 years or above.

Results

A total number of 25 525 HIV/AIDS patients were enrolled in this study. During the follow-up period, the overall mortality among all the patients was 24.9%. Mortality of those having received the highly active antiretroviral treatment (HAART) was 14.4%. Proportion for the treatment coverage increased gradually, from 72.1% in 2008 to 92.8% in 2015. The overall mortality rate dropped from 21.2% to 4.1% and the mortality of those having received HAART patients dropped from 9.2% to 2.6%. Results from the multiple factors analysis showed that factors as: CD(4)(+) T cell count (CD(4)) <50 cell/μl when the AIDS diagnosis was made (adjusted HR=2.45) were related to higher risk on mortality among HIV/AIDS patients. Patients having received HAART (adjusted HR=0.13) had lower risks on mortality. Among patients having received treatment, results from the multiple factors analysis showed that factor as TMP-SMZ dosage being administered (adjusted HR=0.76) were related to low mortality risk. As for CD(4) counts of the patients, the adjusted HRs were 1.26 in 50-cells/μl group and 1.97 in the <50 cells/μl group, respectively when the diagnosis was made. Both groups had high risk on mortality patients with lower baseline CD(4) counts (adjusted HR were 1.44, 1.84 in 50-cells/μl and <50 cells/μl groups, respectively) seemed to have higher risk on mortality.

Conclusions

Antiretroviral therapy appeared an important factor that affecting the survival of HIV/AIDS patients. CD(4) count test, early identifying and treating the AIDS patients together with providing TMP-SMZ prevention and treatment programs, were important approaches in extending the survival time so as to reduce the death rates from AIDS related illnesses.