Annals of agricultural and environmental medicine : AAEM · 2018
IgE-dependent sensitization in patients with COPD.
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Bożek Andrzej, Rogala Barbara
Аннотация
INTRODUCTION AND OBJECTIVE: The aim of the study was to evaluate the differences between asthma and COPD on the basis of the prevalence and profile of IgE-dependent sensitization to inhaled allergens, and the blood serum levels of select Th1/Th2 cytokines.
MATERIAL AND METHODS: 103 patients with COPD (114 patients with asthma and 121 controls) were included in the study. A skin prick test with common inhaled allergens was performed, and serum levels of IgE were measured in all subjects. Lymphocyte profiles were measured via the whole-blood method using fresh 10-ml blood samples treated with EDTA. The following surface antigens were measured: CD3, CD29, CD16, CD56, CD4, CD8, and HLA-DR. The Th1/Th2 profile in blood serum was determined using Th1/Th2 cytokine kits.
RESULTS: IgE-dependent sensitization to environmental allergens was found in 34 (33.3%) patients with COPD, 46 (40%) patients with asthma and in 14 (11.5%) volunteers. The odds ratio of sensitization in patients with COPD reached 0.89 (95% CI: 0.57-1.08) and it was more frequent than in the control population with an odds ratio of 0.71 (95% CI: 0.64-0.88). The serum concentration of IL-2 was significantly higher in patients with COPD and asthma than in controls. In the subgroup of patients with non-allergic asthma, similar serum concentrations were observed for all analyzed cytokines, except for IFN-gamma, which was lower in patients with COPD.
CONCLUSIONS: Both the prevalence and profile of IgE-dependent sensitization to inhaled allergens did not differ between asthma and COPD. Both Th2 and Th1 played a role in the immunopathology of asthma and COPD.
ABBREVIATIONS: COPD - Chronic Obstructive Pulmonary Disease; FEV1 - forced expiratory volume in one second; FVC - forced expiratory volume; GINA - Global Initiative for Asthma; GOLD - Global Initiative for Chronic Obstructive Lung Disease; MMRC - Modified Medical Research Council; Th1 - lymphocyte helper 1; Th2 - lymphocyte helper 2.
MATERIAL AND METHODS: 103 patients with COPD (114 patients with asthma and 121 controls) were included in the study. A skin prick test with common inhaled allergens was performed, and serum levels of IgE were measured in all subjects. Lymphocyte profiles were measured via the whole-blood method using fresh 10-ml blood samples treated with EDTA. The following surface antigens were measured: CD3, CD29, CD16, CD56, CD4, CD8, and HLA-DR. The Th1/Th2 profile in blood serum was determined using Th1/Th2 cytokine kits.
RESULTS: IgE-dependent sensitization to environmental allergens was found in 34 (33.3%) patients with COPD, 46 (40%) patients with asthma and in 14 (11.5%) volunteers. The odds ratio of sensitization in patients with COPD reached 0.89 (95% CI: 0.57-1.08) and it was more frequent than in the control population with an odds ratio of 0.71 (95% CI: 0.64-0.88). The serum concentration of IL-2 was significantly higher in patients with COPD and asthma than in controls. In the subgroup of patients with non-allergic asthma, similar serum concentrations were observed for all analyzed cytokines, except for IFN-gamma, which was lower in patients with COPD.
CONCLUSIONS: Both the prevalence and profile of IgE-dependent sensitization to inhaled allergens did not differ between asthma and COPD. Both Th2 and Th1 played a role in the immunopathology of asthma and COPD.
ABBREVIATIONS: COPD - Chronic Obstructive Pulmonary Disease; FEV1 - forced expiratory volume in one second; FVC - forced expiratory volume; GINA - Global Initiative for Asthma; GOLD - Global Initiative for Chronic Obstructive Lung Disease; MMRC - Modified Medical Research Council; Th1 - lymphocyte helper 1; Th2 - lymphocyte helper 2.