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Войти в исследования The Pan African medical journal · 2026
Ongoing transmission of human onchocerciasis in blackflies in the medical district of Mont Ngafula 1 in Kinshasa after nearly two decades of uninterrupted onchocerciasis mass campaigns using community-directed treatment with ivermectin strategy.
СтатьяНазвание и аннотация: Перевод в очереди
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Bof Jean Claude Makenga, Mansiangi Paul, Zanga Josué, Ilunga-Ilunga Félicien, Adjami Ako Aime Gilles, Sounkalo Sanfo Moussa, Bakajika Didier, Coppieters Yves
Аннотация
INTRODUCTION: the medical district of Mont Ngafula 1 in Kinshasa, the capital city of the Democratic Republic of Congo (DRC), has been treated for onchocerciasis for over 16 years using Community-Directed Treatment with Ivermectin strategy (CDTI). This study aimed to determine blackfly infectivity rate and annual transmission potential in the Mont Ngafula medical district using O-150 PCR assay after four additional annual rounds of mass drug administration (MDA) following the initial entomological survey from August 2014 to July 2015.
METHODS: this was a longitudinal entomological study. Blackflies were collected at the Kimwenza collection site in the Mont Ngafula medical district from 1st August 2019 to 31st July 2020 using the human landing collection technique. The WHO-recommended O-150 pool screening polymerase chain reaction assay was used to determine the blackfly infectivity rate and annual transmission potential.
RESULTS: a cumulative 3,875 female blackflies were collected, and Simulium squamosum was identified as the main vector species. The infectivity rate was 0.75 % (95% CI: 0.48-1.13) with an annual transmission potential of 254 (95% CI: 153-396).
CONCLUSION: these findings confirm the persistent transmission of human onchocerciasis in the Mont Ngafula 1 medical district despite 16 years of ivermectin distribution using the Community-Directed Treatment with Ivermectin strategy. They highlight the urgent need for alternative treatment strategies to accelerate the interruption and elimination of onchocerciasis transmission.
METHODS: this was a longitudinal entomological study. Blackflies were collected at the Kimwenza collection site in the Mont Ngafula medical district from 1st August 2019 to 31st July 2020 using the human landing collection technique. The WHO-recommended O-150 pool screening polymerase chain reaction assay was used to determine the blackfly infectivity rate and annual transmission potential.
RESULTS: a cumulative 3,875 female blackflies were collected, and Simulium squamosum was identified as the main vector species. The infectivity rate was 0.75 % (95% CI: 0.48-1.13) with an annual transmission potential of 254 (95% CI: 153-396).
CONCLUSION: these findings confirm the persistent transmission of human onchocerciasis in the Mont Ngafula 1 medical district despite 16 years of ivermectin distribution using the Community-Directed Treatment with Ivermectin strategy. They highlight the urgent need for alternative treatment strategies to accelerate the interruption and elimination of onchocerciasis transmission.