Endocrine research · 2025
Predictive Value of LncRNA LINC01184 in Papillary Thyroid Cancer Development and Prognosis and Its Regulatory Effect on Cellular Processes.
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Sun Yi, Hu Wanping, Huang Jianyuan, Liu Zhi
Аннотация
INTRODUCTION: This study assessed the potential of lncRNA LINC01184 in predicting PTC progression and prognosis and its regulatory mechanism in PTC cellular processes, aiming to explore a novel biomarker for PTC.
METHODS: The study enrolled 111 PTC patients and collected paired tissue samples. Using PCR, the expression of LINC01184 was analyzed, and its association with patients' clinicopathological features and prognosis was evaluated. The regulatory effects of LINC01184 on cell growth and metastasis were assessed by CCK8 and Transwell assays.
RESULTS: LINC01184 was significantly downregulated in PTC, which was closely correlated with poor differentiation, advanced TNM stage, the occurrence of lymph node metastasis, and poor overall survival. In PTC cells, LINC01184 negatively regulated miR-296-3p, and its overexpression suppressed cell growth and metastasis of PTC, which was reversed by overexpressing miR-296-3p.
CONCLUSION: Downregulated LINC01184 served as a biomarker for PTC. Overexpressing LINC01184 suppressed PTC cell progression via suppressing miR-296-3p.
METHODS: The study enrolled 111 PTC patients and collected paired tissue samples. Using PCR, the expression of LINC01184 was analyzed, and its association with patients' clinicopathological features and prognosis was evaluated. The regulatory effects of LINC01184 on cell growth and metastasis were assessed by CCK8 and Transwell assays.
RESULTS: LINC01184 was significantly downregulated in PTC, which was closely correlated with poor differentiation, advanced TNM stage, the occurrence of lymph node metastasis, and poor overall survival. In PTC cells, LINC01184 negatively regulated miR-296-3p, and its overexpression suppressed cell growth and metastasis of PTC, which was reversed by overexpressing miR-296-3p.
CONCLUSION: Downregulated LINC01184 served as a biomarker for PTC. Overexpressing LINC01184 suppressed PTC cell progression via suppressing miR-296-3p.