Journal of functional biomaterials · 2025
Eighty-Four-Month Clinical Outcomes of Autologous Dentin Graft Using Tooth Transformer® and Concentrated Growth Factors in Maxillary Atrophy: A Retrospective Study of 31 Patients.
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Dipalma Gianna, Inchingolo Alessio Danilo, Calò Francesca, Lagioia Rosalba, Bassi Paola, de Ruvo Elisabetta, Inchingolo Francesco, Palermo Andrea, Marinelli Grazia, Inchingolo Angelo Michele
Аннотация
AIM: This retrospective observational clinical cohort study evaluated 84-month clinical and radiographic outcomes of a regenerative protocol combining autologous dentin grafts processed with the Tooth Transformer® device and Concentrated Growth Factors (CGFs) in patients with severe maxillary atrophy undergoing sinus augmentation with simultaneous implant placement.
MATERIALS AND METHODS: Thirty-one patients (30-75 years) with residual crestal bone height ≥ 5 mm and requiring extraction of ≥2 molars were included. Extracted teeth were processed with the Tooth Transformer® to obtain demineralized dentin granules (500-1000 µm), which were combined with CGFs prepared using the Medifuge MF200® to form "sticky bone." All patients underwent sinus lift via a lateral window approach (Hilt Tatum technique) with simultaneous placement of 98 implants (12-14 mm), which were loaded after six months.
RESULTS: At the 84-month follow-up, no implant failures or peri-implantitis were recorded. CBCT and clinical evaluations showed stable regenerated bone volume and absence of peri-implant bone resorption. All patients received fixed prostheses within six months without complications.
CONCLUSIONS: The combined use of processed autologous dentin and CGFs proved to be a safe, predictable, and effective regenerative technique in cases of severe maxillary atrophy, with a 100% implant survival rate at five years.
MATERIALS AND METHODS: Thirty-one patients (30-75 years) with residual crestal bone height ≥ 5 mm and requiring extraction of ≥2 molars were included. Extracted teeth were processed with the Tooth Transformer® to obtain demineralized dentin granules (500-1000 µm), which were combined with CGFs prepared using the Medifuge MF200® to form "sticky bone." All patients underwent sinus lift via a lateral window approach (Hilt Tatum technique) with simultaneous placement of 98 implants (12-14 mm), which were loaded after six months.
RESULTS: At the 84-month follow-up, no implant failures or peri-implantitis were recorded. CBCT and clinical evaluations showed stable regenerated bone volume and absence of peri-implant bone resorption. All patients received fixed prostheses within six months without complications.
CONCLUSIONS: The combined use of processed autologous dentin and CGFs proved to be a safe, predictable, and effective regenerative technique in cases of severe maxillary atrophy, with a 100% implant survival rate at five years.