Emerging infectious diseases · 2026
Border Region Surveillance of Malaria Drug Resistance, Northern Burundi, 2023-2024.
СтатьяНазвание и аннотация: Перевод в очереди
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Niyomwungere Denis, Sinarinzi Pierre, Caspar Emmanuelle, Thiebaut Lucas, Strubel Pierre-Emeric, Tibiri Yssimini Nadège Guillène, Ma Laurence, Rurihafi Jérôme, Ndizeyimana Pierre, Hakizimana Pierre, Niyizompa Nestor, Witonze Adélin, Ndayiragije Vénant, Ndayisenga Floride, Ndikumukiza Malachie, Niyonkuru Olive, Niyonsaba Jean Claude, Bangirinama Césaire, Bigirimana Jolis Lazare, Ntahondi Nicaise, Mugisha Landrine, Nibakire Marcelline, Nzoyikorera Néhémie, Sinzinkayo Denis, Menard Didier, Nyandwi Joseph
Аннотация
To evaluated artemisinin partial resistance (ART-R) in malaria in Burundi, during December 2023-June 2024, we studied 423 children <5 years of age with uncomplicated Plasmodium falciparum malaria in 8 health facilities in the northern part of the country. After artemether/lumefantrine treatment with only the first dose directly observed, 4.5% remained parasitemic on day 3. No pfkelch13 mutations, validated or candidate markers of ART-R, were detected. However, markers of antifolate and 4-aminoquinoline resistance were widespread: the dhfr triple mutant N51I/C59R/S108N was nearly fixed (92%), dhps double and triple mutants were common (41% and 47%), and pfcrt CVIET, associated with chloroquine and amodiaquine resistance, predominated (84%). Geographic differences occurred in day-3 positivity and haplotype frequencies. Although ART-R markers were absent, delayed parasite clearance and near fixation of multidrug-resistant haplotypes serve as a warning. Strengthened efficacy monitoring and regional molecular surveillance are urgently needed to prevent drug-resistant P. falciparum from becoming established in Burundi.