BMC nephrology · 2026
Effect of a transfer- and ambulation-focused early mobilization protocol on functional capacity after kidney transplantation: a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Li Guo, Wang Miao-Wei, Zhang Xia, Wang Ao, Wu Yu-Qi, Zhang Li, Gao Qiang
Аннотация
BACKGROUND: Early mobilization is recommended to improve postoperative recovery, yet implementation after kidney transplantation is often delayed or limited.
OBJECTIVES: To determine whether a transfer- and ambulation-focused early mobilization protocol improves early postoperative exercise capacity and mobilization in kidney transplant recipients(KTRs), and to evaluate its safety and feasibility.
METHODS: Single-center, randomized, parallel-group controlled trial conducted at West China Hospital, Sichuan University (Chengdu, China). Fifty-four adults undergoing kidney transplantation were randomized 1:1 postoperatively to usual care (control group) or usual care plus an early transfer- and ambulation-focused mobilization protocol (early mobilization group, EMG). The primary outcome was the 6-minute walk distance (6-MWD) on postoperative day(POD) 7; secondary outcomes included 6-MWD change from baseline, grip strength, grip strength change from baseline, laboratory indices, prespecified safety and feasibility endpoints, postoperative complications, and hospital length of stay.
RESULTS: Baseline characteristics were comparable between groups. Compared with CG, EMG achieved shorter bed rest time, better 6-MWD (with a smaller postoperative decline from baseline where available), and lower white blood cell (WBC) count on POD7 (all p < 0.05). No participant in EMG was graded as "unable to complete" the mobilization protocol, and no protocol-related adverse events were observed.
CONCLUSIONS: A transfer- and ambulation-focused early mobilization protocol improved early postoperative functional capacity and mobilization in KTRs and appeared safe and feasible.
TRIAL REGISTRATION: http://www.chictr.org.cn ChiCTR2400086546(07/04/2024).
OBJECTIVES: To determine whether a transfer- and ambulation-focused early mobilization protocol improves early postoperative exercise capacity and mobilization in kidney transplant recipients(KTRs), and to evaluate its safety and feasibility.
METHODS: Single-center, randomized, parallel-group controlled trial conducted at West China Hospital, Sichuan University (Chengdu, China). Fifty-four adults undergoing kidney transplantation were randomized 1:1 postoperatively to usual care (control group) or usual care plus an early transfer- and ambulation-focused mobilization protocol (early mobilization group, EMG). The primary outcome was the 6-minute walk distance (6-MWD) on postoperative day(POD) 7; secondary outcomes included 6-MWD change from baseline, grip strength, grip strength change from baseline, laboratory indices, prespecified safety and feasibility endpoints, postoperative complications, and hospital length of stay.
RESULTS: Baseline characteristics were comparable between groups. Compared with CG, EMG achieved shorter bed rest time, better 6-MWD (with a smaller postoperative decline from baseline where available), and lower white blood cell (WBC) count on POD7 (all p < 0.05). No participant in EMG was graded as "unable to complete" the mobilization protocol, and no protocol-related adverse events were observed.
CONCLUSIONS: A transfer- and ambulation-focused early mobilization protocol improved early postoperative functional capacity and mobilization in KTRs and appeared safe and feasible.
TRIAL REGISTRATION: http://www.chictr.org.cn ChiCTR2400086546(07/04/2024).