Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO).
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Specovius Svenja, Zimmermann Hanna G, Oertel Frederike Cosima, Chien Claudia, Bereuter Charlotte, Cook Lawrence J, Lana Peixoto Marco Aurélio, Fontenelle Mariana Andrade, Kim Ho Jin, Hyun Jae-Won, Jung Su-Kyung, Palace Jacqueline, Roca-Fernandez Adriana, Diaz Alejandro Rubio, Leite Maria Isabel, Sharma Srilakshmi M, Ashtari Fereshte, Kafieh Rahele, Dehghani Alireza, Pourazizi Mohsen, Pandit Lekha, Dcunha Anitha, Aktas Orhan, Ringelstein Marius, Albrecht Philipp, May Eugene, Tongco Caryl, Leocani Letizia, Pisa Marco, Radaelli Marta, Martinez-Lapiscina Elena H, Stiebel-Kalish Hadas, Hellmann Mark, Lotan Itay, Siritho Sasitorn, de Seze Jérôme, Senger Thomas, Havla Joachim, Marignier Romain, Tilikete Caroline, Cobo Calvo Alvaro, Bichuetti Denis Bernardi, Tavares Ivan Maynart, Asgari Nasrin, Soelberg Kerstin, Altintas Ayse, Yildirim Rengin, Tanriverdi Uygur, Jacob Anu, Huda Saif, Rimler Zoe, Reid Allyson, Mao-Draayer Yang, de Castillo Ibis Soto, Yeaman Michael R, Smith Terry J, Brandt Alexander U, Paul Friedemann, GJCF International Clinical Consortium for NMOSD
Аннотация
PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices.
FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline.
FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.