Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Buckles Virginia D, Xiong Chengjie, Bateman Randall J, Hassenstab Jason, Allegri Ricardo, Berman Sarah B, Chhatwal Jasmeer P, Danek Adrian, Fagan Anne M, Ghetti Bernardino, Goate Alison, Graff-Radford Neill, Jucker Mathias, Levin Johannes, Marcus Daniel S, Masters Colin L, McCue Lena, McDade Eric, Mori Hiroshi, Moulder Krista L, Noble James M, Paumier Katrina, Preische Oliver, Ringman John M, Fox Nick C, Salloway Stephen, Schofield Peter R, Martins Ralph, Vöglein Jonathan, Morris John C, Dominantly Inherited Alzheimer's Network
Аннотация
As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.