Drug reaction with eosinophilia and systemic symptoms: An emergency medicine focused review.

INTRODUCTION

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction associated with potentially severe morbidity and mortality.

OBJECTIVE

This narrative review evaluates the pathogenesis, diagnosis, and management of DRESS for emergency clinicians.

DISCUSSION: DRESS is a severe hypersensitivity reaction which can involve multiple organ systems, including the skin, lymphatic system, lungs, kidneys, and heart. Treatment is primarily supportive care combined with removal of the offending agent and initiation of corticosteroids. Additional options include cyclophosphamide, cyclosporine, intravenous immunoglobulin, and N-acetylcysteine.

CONCLUSION

It is important for the emergency clinician to be aware of the diagnosis and management of DRESS in order to best optimize care for these patients.