Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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De Smet Stefanie, Int-Veen Isabell, Vanhollebeke Gert, Pulopulos Matias M, Barth Beatrix, Pasche Sarah, Baeken Chris, Nuerk Hans-Christoph, Plewnia Christian, Nieratschker Vanessa, Jochen Fallgatter Andreas, Ehlis Ann-Christine, Vanderhasselt Marie-Anne, Rosenbaum David
Аннотация
OBJECTIVE: Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.
METHODS: In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.
RESULTS: Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.
CONCLUSIONS: cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.
SIGNIFICANCE: These findings highlight the importance of accounting for individual differences when examining TBS effects.
METHODS: In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.
RESULTS: Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.
CONCLUSIONS: cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.
SIGNIFICANCE: These findings highlight the importance of accounting for individual differences when examining TBS effects.