International journal of radiation oncology, biology, physics · 2003
Long-term results of proton beam therapy for carcinoma of the uterine cervix.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kagei Kenji, Tokuuye Koichi, Okumura Toshiyuki, Ohara Kiyoshi, Shioyama Yoshiyuki, Sugahara Shinji, Akine Yasuyuki
Аннотация
PURPOSE: To determine the role of proton therapy in patients with carcinoma of the uterine cervix.
METHODS AND MATERIALS: Between 1983 and 1991, 25 patients with squamous cell carcinoma of the uterine cervix (stages IIB-IVA) were treated with a curative intent by external photon irradiation to the pelvis, followed by proton irradiation to the primary tumor, delivering a median total tumor dose of 86 Gy (range 71 Gy/26 Fr-101 Gy/46 Fr), and were followed for a median period of 139 months (range 11-184 months).
RESULTS: Ten-year overall survival rates for stages IIB and IIIB/IVA patients were 89% and 40%, respectively. Five-year local control rates for stages IIB and IIIB/IVA patients were 100% and 61%, respectively. Four percent of patients experienced severe (Grade 4 or more) late complications in the intestine or urinary bladder at 5 years.
CONCLUSION: External photon and proton therapy is effective for those who are not eligible for intracavitary irradiation, and who otherwise have a poor prognosis. The results show that tumor control, survival, and morbidity are similar to those after conventional therapy.
METHODS AND MATERIALS: Between 1983 and 1991, 25 patients with squamous cell carcinoma of the uterine cervix (stages IIB-IVA) were treated with a curative intent by external photon irradiation to the pelvis, followed by proton irradiation to the primary tumor, delivering a median total tumor dose of 86 Gy (range 71 Gy/26 Fr-101 Gy/46 Fr), and were followed for a median period of 139 months (range 11-184 months).
RESULTS: Ten-year overall survival rates for stages IIB and IIIB/IVA patients were 89% and 40%, respectively. Five-year local control rates for stages IIB and IIIB/IVA patients were 100% and 61%, respectively. Four percent of patients experienced severe (Grade 4 or more) late complications in the intestine or urinary bladder at 5 years.
CONCLUSION: External photon and proton therapy is effective for those who are not eligible for intracavitary irradiation, and who otherwise have a poor prognosis. The results show that tumor control, survival, and morbidity are similar to those after conventional therapy.
Предметные рубрики MeSH
AgedCarcinoma, Squamous CellCobalt RadioisotopesColitisCystitisDose Fractionation, RadiationEnteritisFemaleFollow-Up StudiesHumansLife TablesMiddle AgedPhotonsRadiation InjuriesRadioisotope TeletherapyRadiotherapy Planning, Computer-AssistedSurvival RateSynchrotronsTreatment OutcomeUterine Cervical Neoplasms