The effect of left ventricular function on the echocardiographic assessment of heart valve disease.

Transvalvar velocities or derived pressure differences are highly dependent on flow. They must be corrected for flow for research studies or in the clinical situation where values are intermediate and difficult to interpret. This can be done using the continuity equation or using formulae based on ratios of mean pressure drop and flow of which resistance is probably more accurate than the Gorlin formula. Left ventricular diastolic behavior is a major determinant of mitral pressure half-time where the mitral stenosis is mild and also of the slope of the continuous wave recording in mild or moderate aortic regurgitation. Methods for assessing mitral regurgitation including patterns of pulmonary vein flow are also dependent on left ventricular function. The echocardiographic methods of describing valve function cannot be interpreted without regard to left ventricular function and loading conditions.