Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego · 2004
[Description of an experimental model of hepatorenal syndrome in Wistar rats].
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Saracyn Marek, Kozłowski Wojciech, Wańikowicz Zofia
Аннотация
UNLABELLED: In spite of many years of experimental and clinical studies, it failed to discover precise pathomechanisms leading from hepatic damage to functional renal failure in hepatorenal syndrome (HRS). There are few reported animal models of hrs, among them a rat model induced by galactosamine (Ga1N). In this model renal failure develops typically after hepatic damage in male Sprague-Dawley rats. In our study we tried to test, whether other breeds develop typical HRS.
MATERIAL AND METHODS: We used male Wistar rats to achieve acute liver and renal failure by intraperitoneal injection of Ga1N. Liver failure developed with significant increase in serum concentration of bilirubin, AST, ALT; ammonia and massive necrosis of hepatocytes. Nevertheless, we did not achieve increase of serum creatinine and urea typical for acute renal failure.
CONCLUSIONS: We concluded that only some of rat breeds develop typical hrs, maybe because of some congenital, genetic predispositions.
MATERIAL AND METHODS: We used male Wistar rats to achieve acute liver and renal failure by intraperitoneal injection of Ga1N. Liver failure developed with significant increase in serum concentration of bilirubin, AST, ALT; ammonia and massive necrosis of hepatocytes. Nevertheless, we did not achieve increase of serum creatinine and urea typical for acute renal failure.
CONCLUSIONS: We concluded that only some of rat breeds develop typical hrs, maybe because of some congenital, genetic predispositions.